More Gut Bacteria Research: This time with Cancer treatments

From New Scientist:

How well a cancer treatment works might depend on what’s living in your gut. Two studies in mice have shown that gut bacteria can influence the effectiveness of treatments for cancer.

Drugs such as ipilimumab, which is given to people with advanced melanoma, work by activating the immune system to help it fight cancer.

Some people who take the drug experience inflammation in the gut. This led Mathias Chamaillard at the University of Lille, France, to wonder whether gut bacteria might be interacting with the drug.

To investigate, Chamaillard and his colleagues gave ipilimumab to mice that lack bacteria in their gut. The drug wasn’t as effective at treating cancer in these mice compared with mice with normal gut bacteria. The effectiveness of the drug also decreased when the normal mice were given antibiotics to wipe out their gut bacteria.

Faecal samples revealed that ipilimumab caused a decrease in two types of bacteria, Bacteroidales and Burkholderiales, in the gut. Replenishing these microbes in both sets of mice restored the efficacy of the drug.

There’s more; click the link.

Advertisements

Leave a comment

Filed under Health, Science

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s